our journey of hope and healing through autism

Science Saturday: ADHD, atemoxetine, and cytochrome p-450


Art by E., grade 3


Some of our genetic tests are back (E.’s didn’t work and needs to be repeated), and I’m busy researching and trying to understand the implications of what we’ve learned.

One thing that I find fascinating is that there are genes that make ADHD meds more and less effective.  Meds are something that we have worked really hard to avoid using for E., but have ended up using anyway.  As we’re back to working hard to use nutritional supports instead  I was happy to learn about this blogger, who blogs extensively about the science and research surrounding nutritional and pharmaceutical approaches to helping ADHD.  One interesting topic he discusses in depth is the effect of genes on ADHD.

I’ve learned that some interesting things.

One of the genes is part of the cytochrome p-450 family.  CYP2D6 is a gene that breaks down atemoxetine, which E. is currently taking.  One study found if a person has  a genetic mutation that causes atemoxetine to be slowly broken down, they’ll have more side effects, but better ADHD symptom relief.  Definately not a magic bullet!   I have one copy of the slow moving gene.  I’ll be interested to see what Evan’s gene report says when it comes!

* CYP2D6 isn’t the only gene working on atemoxetine, this study looked at others.


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This entry was posted on February 15, 2014 by in ADHD, Science Saturday, What's Up Lately and tagged , .
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